The Grim Adventures of Billy and Mandy (2001)

Season 1: Episode 3

Billy and Mandy tell Grim it is "Opposite Day" and that, when they say something, they really mean the opposite. Due to his difficulty understanding the concept of Opposite Day, Grim has to do Mandy's chores. Finally, Grim thinks he understands when Billy and Mandy say they "want" pie, meaning they "do not want" pie. However, Mandy then says that when she said it was Opposite Day, it really was not.